Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity
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چکیده
منابع مشابه
Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity.
Computational protein design methods were used to predict five variants of monofunctional Escherichia coli chorismate mutase expected to maintain catalytic activity. The variants were tested experimentally and three active site mutants exhibited catalytic activity similar to or greater than the wild-type enzyme. One mutant, Ala32Ser, showed increased catalytic efficiency.
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2018
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1800380